I don't do anything to my guitars until something breaks, with the one exception of adding an Invader to the Ibanez. All I've had to do at this point is replace pickup selector switches and a couple of jacks.
And, as a bit of trivia, Mike Campbell of Tom Petty and the Heartbreakers has a Broadcaster that he claims never to have taken the neck off of. The interview also says that all he's had to replace was *1* fret that had worn out.
Guitars:
Fender 2006 MIM Fender Stratocaster HSS in 3TS
Ibanez RG 570 with a bridge Invader
ESP M II Deluxe with a Tune-o-Matic bridge
Eleanor, the magical, mystical Road Worn wonder Tele
Blackstar HT Club 40