From a gigging perspective and having to cover lots of sonic ground.......ease of use, and sounding great:
Fractal Audio's Axe FX. Not cheap by any stretch, but once learned can deliver just about any tone you hear in your head - and sound great live doing it.
I own a couple of primo tube amps, but my Axe FX is still my go to rig.
It's that good.
Guitars: 2008 Gibson SG Classic, 2006 Gibson Les Paul Standard LE, 2002 Gibson SG Supreme, 2001 Gibson Les Paul Studio Plus, 1996 Les Paul Studio Gem, American Deluxe Double Fat Strat, Bluesville "Super" Strat Copy, MIK Fender "Limited Edition" Tele, JD Bluesville "Night Pilot", Yamaha AES 820, Steinberger Spirit GT Pro, Taylor 355CE, Ovation 1897 Adamas, Ovation CC057 Celebrity
Amps: Axe FX centered rack rig, Mesa 4x12 cab. Germino Club 40, Johnson JM150 Millennium, Johnson JM250 Millennium, Gibson Titan Medalist Frankenstein.
Effects: Tonebone Trimode, EH Holy Grail, Boss CH-1, Dunlop Crybaby Classic, Framptone Amp Switcher, THD Hot Plate, Yamaha AG Stomp Acoustic Processor, Boss BCB-60 Pedal Board.