Yup I do stuff like that all the time. You might want to arm yourself with a few adaptors to do turn arounds with.
For example I will use one of my XLRs to send a DMX signal back through or if I want to link my subs ( self powered) I will use a turn around to send the signal back through the snake.
The snake is just a bundle of wires, don't over think it,just use the right adaptor to get where your going in either direction.
Remember to never send a amp output or something like that through it,mainly balanced connections!!! NO POWER!!!!!!
Oh yeah "Y" connections suck.
I try to use only one channel of snake per signal,be it XLR ,TRS. I have adaptors for most situations as well as DI's and Balancing tfmr's.