Quit playing with amps live about 2 yrs ago, I ain't looking back.
GSP 1101 into the PA stereo, I get all I need in my monitor ,the FOH is clean sounding and my back is Happy!

I have MP-1s Voodu Valves, 2112 and cabs out the ying yang collecting dust.
I agree that I miss the dynamics of a cabinet blowing my knees away,I have 2 4x12s that I love, but modeling is a great tool if you know and understand EQing. You can really get some useable sounds out of most modelers the key is as Spud said TWEAK IT!