One thing I've noticed about strats is that the action is typically higher than lots of other guitars. When I'm up above the 15th fret doing bends my fingers go under the lower strings - this after a pro setup by a local luthier. The action on strats isn't supposed to be shred-master low. On a Peavey Predator I recently picked up I initially set the action very low and wasn't happy with the way it played at all. So I put a little relief in the neck and raised the saddles - wooola! Nice player.

Kinda depends on what you like I guess - a pro setup would be the best way to see what a pro says it should be setup like.