While I readily admit my addiction to the smell of solder smoke, I also have to admit that the George L solder-less cables I have used have never been a problem, and yes, they do sound outstanding if you like a low capacitance cable. Nothing gets lost. The first time I started using one it made me realize there was nothing wrong with the pickups and pots I was planning on replacing in a particular guitar, the problem was the tone sucking Monster cablesI was using. Since then I have been very particular about cables.
If someone is typically playing through a bunch of pedals and a buffer I'm not sure that the clarity of something like a George L would be as noticeable or as important, but if you like going straight in to your amp and use the volume and tone controls on it to shape your sound, you'll love the difference.
In any case, the solder free design is simple and quick and always worked fine for me,