With a loop pedal, you could lay a good solid drum track down with your drum machine, layer clean guitar track(s) over it, make several loops of your favorite songs, played through one amph, and then use another amph to play lead along with it, if you want to use effects and not color the drums too much.
Wilburn Versatare, '52 FrankenTele(Fender licensed parts), Fender USA Roadhouse Strat, Fender USA Standard B-bender Telecaster, Agile AL 3000 w/ WCR pickups, Ibanez MIJ V300 Acoustic, Squier Precision Bass,
Ceriatone Overtone Special, Musicman 212 Sixty-Five, Fender Blues Jr., Peavey Classic 30, Fender Super Reverb, Traynor YCV-40 WR Anniversary w/ matching 1x12 ext. cab, Epiphone SoCal 50w head w/ matching 4x12 cab (Lady Luck speakers), Avatar 2x12 semi-open back cab w/ Celestion speakers
Digitech Bad Monkey, Digitech Jamman, DVM's ZYS, Goodrich volume pedal