Birv,
It's amazing just how much your sound can change from home to on a stage, isn't it? I play fairly regular gigs, and my sound is different from room to room. Turning down the gain is good advice. Too much gain drains your midrange punch, and that is where guitars make their living. The same goes for too much reverb or other modulating FX. That's not saying to play naked - just use your gain and modulation FX sparingly - a little dab will do you on a stage. Take some time to EQ your rig to the spot where it will sit in nicely with the rest of the mix but still be distinctive. This might take a tune or two in the heat of battle to dial in. After a few live shows, you'll have a baseline EQ to use as a reference, but keep in mind it changes from room to room.
Guitars: 2008 Gibson SG Classic, 2006 Gibson Les Paul Standard LE, 2002 Gibson SG Supreme, 2001 Gibson Les Paul Studio Plus, 1996 Les Paul Studio Gem, American Deluxe Double Fat Strat, Bluesville "Super" Strat Copy, MIK Fender "Limited Edition" Tele, JD Bluesville "Night Pilot", Yamaha AES 820, Steinberger Spirit GT Pro, Taylor 355CE, Ovation 1897 Adamas, Ovation CC057 Celebrity
Amps: Axe FX centered rack rig, Mesa 4x12 cab. Germino Club 40, Johnson JM150 Millennium, Johnson JM250 Millennium, Gibson Titan Medalist Frankenstein.
Effects: Tonebone Trimode, EH Holy Grail, Boss CH-1, Dunlop Crybaby Classic, Framptone Amp Switcher, THD Hot Plate, Yamaha AG Stomp Acoustic Processor, Boss BCB-60 Pedal Board.