Now that I'm getting more familiar with the Valvetronix, it's getting easier to tweak a good tone.

Initially, I had two dirty settings saved, and was going to use the manual mode as the 3rd channel for clean. Using the Boutique OD model, I saved one to channel 1 for the neck pup of my strat, and channel 2 for the bridge pup. Interestingly, the difference was so subtle I stuck with just one dirt setting.

This really made the strings ring out pretty well without getting muddy or overly distorted...

Gain: 10:00
Bass: 9:00-10:00
Mid: 1:00
Treble: 2:00
Reverb: 9:00
NR: Off

With the AD100VT, I notice alot of bottom end and midrange on the amp so I dropped the bass on the amp and can always roll of the treble on my guitar tone knob.