I think another big difference will be which neck you may like better?
The Roadhouse having the C shape.
The Jimmie Vaughan having the soft V shape.

I fell in love with the JV neck...

I would suggest trying each out before the purchase if possible..
For sound and feel..

Edit: looks like Strum and I mentioned this at the same moment..
Go feel them... it probably will be the decision maker..: