Yes.
I've now & then re-strung my Guild D40 Nashville, but just standard tuning. No special set, just all plain steels for these 5: 1/E .010, 2/B .013 or .014, 3/G .009 or .010, 4/D .012 or .013, 5/A .016 or .017; and an electric nickel wound .024 or.026 for 6/E.
No adjustment needed because I've strung my acoustic 6's xtra light ( .010-.047) to make going back & forth with electric 6's strung .010-.046 fairly seamless. But if you string the acoustic as most folks do, .012-.053, you may have to tweak the truss rod/neck relief.
Most useful application is the one Nashville studio cats concocted it for back in the stone age 1950's and thus the name: to double a 'normally strung' acoustic 6 part in a recording, overdubbing with a 2nd track.