One thing is cool, though, about a big amph through a 4x12 cab is the WHUMP. Turn that amph up, stand in front of the cab, and hit a power chord. The feeling when the sound hits you in the chest (the WHUMP, that's the best way I can describe it) is incredible. There really is nothing like it.
Of course, there really is nothing like tinnitus either, so I like my smaller amph. 
Guitars:
Fender 2006 MIM Fender Stratocaster HSS in 3TS
Ibanez RG 570 with a bridge Invader
ESP M II Deluxe with a Tune-o-Matic bridge
Eleanor, the magical, mystical Road Worn wonder Tele
Blackstar HT Club 40
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