I usually goto the one with the newest strings, which is usually the newest aquired or the one with the newest mods or simply just the one with the newest strings.

But for comfort reasons...Ive gotta goto a Strat.

I love my Les Paul and my Tele...even my acoustic.
BUT if laying in bed playing or just sitting down, I find the lack of body contours to be numbing at times, weather its across the ribs or the inside forearm...nothing beats a Strat.(but I recon an SG would be comfy too, just dont have one)