I run my MXR Micro Amp (clean boost) first...then into the Marshall Guv 2, the Little Big Muff then the Zonkin' Yellow Screamer then out from that bunch into the NS-2 suppressor loop. I've been using my pedal board almost exclusively these days so I usually have my amps turned up loud on the clean channel and then back off the levels on my pedals. Doing it this way pretty much eliminates me having to boost anything with the clean boost since the clean volume is already loud to begin with and my other pedals are so different from each other, they're already set for their particular sounds so I don't cascade from one pedal into the other. At max gain the Guv and Muff are totally saturated and I just back off my guitar volume to reduce that gain. About the only thing I've done as far as cascading is to set my Muff pedal with low gain/sustain and kick that in on top of the Guv or the Zonkin'. That eliminates having to switch off the Guv first then stomp on the fuzz when I want that saturated fuzz sound. I eliminate one move there.
Guitars/Bass - MIM Fender Classic 50s Strat, MIM Fender Standard Strat, Squier Classic Vibe 50s Tele, Gibson Les Paul Studio, Epi '56 Gold Top Les Paul, Martin DSR acoustic, Sigma Martin Auditorium electric/acoustic, Squier Jazz Bass.
Amps/Cabinets/Modelers - Model 2558 50 watt Marshall Silver Anniversary Jubilee combo w/ Celestion Vintage 30s, 4x12 Marshall cabinet w/25 watt Greenback Celestions, Fender Blues Junior w/ a couple of Billm mods, Line 6 POD 2.0, Roland Micro Cube
Pedals/Effects - Cry Baby Classic Wah, Boss TU-2, Boss NS-2, Boss RC-2 Loop Station, Ross Compressor, MXR Micro Amp, Danelectro FAB Echo, Danelectro FAB Chorus, Danelectro Chicken Salad, Marshall Guv'nor Plus, Marshall Echohead, Duhvoodooman's Zonkin' Yellow Screamer, Digitech Digiverb, Digitech Bad Monkey, Dunlop Fuzz Face, Homemade Loop Bypass pedal, Duhvoodooman's Sonic Tonic (Maxon SD-9 clone +), Voodoo Labs Superfuzz